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XU LABORATORY
INSTITUTE FOR CELL ENGINEERING
DEPARTMENT OF NEUROLOGY | JOHNS HOPKINS SCHOOL OF MEDICINE
Human iPSC for Disease Modelling & Cellular Therapy
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All-In-One human brain miniature
Microglia actively monitor the environment within brain organoids that have vascular endothelia & pericytes experimentally introduced.
CD31/PDGFRβ
(endothelia & pericytes)
Enriched Neural Stem Cells
FOXG1/Nestin neural stem from hiPSC
FOXG1+ neurospheres
Human Cortical Neurons
Layer specific neurons (I - VI)
Balanced excitatory & inhibitory neurons
Midbrain dopaminergic neurons
TH/MAP2
Enriched Astrocytes GFAP & DAPI
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Crosstalk between neurons and astrocytes
MAP2
GFAP
MAP2/GFAP
EGFP hiPSC
&
RFP hiPSC
EGFP hiPSC
RFP hiPSC
Mixed EGFP & RFP hiPSC suspension culture
Microglia precursor cells derived from Yolk Sac
(Differentiated from EGFP & RFP hiPSC)
Vascular Endothelia and Pericytes
Vasculature like meshwork with cardiac microtissues from hiPSC
Cardiac Tissue
3D organotypic cardiac microtissues from hiPSC
Bronchiole (small airway) like structure from hiPSC
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